Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 25;13:983255. doi: 10.3389/fimmu.2022.983255

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Guo, Furuta, Islam, Caporarello, Kostallari, Dielis, Tschumperlin, Hirsova and Ibrahim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Endothelial cell-specific loss of VCAM1 is protective during liver fibrosis. Eight-week-old Vcam1^Δend mice and Vcam1^fl/fl mice were treated with either olive oil or CCl4 intraperitoneally (1μL/g body weight), twice a week for 4 weeks to induce liver fibrosis. (A) Schematic representation of the experimental mouse study. (B) Animal growth curve presented by weight gain during olive oil/CCl4 induction. Liver fibrosis was assessed by (C) mRNA expression of Collagen1a1, (D) Sirius red staining and (E) immunostaining of αSMA. Scale bar: 50μm, n=3-6. *, **, ***, indicate statistical significance with p < 0.05, p < 0.01 and p < 0.001, respectively. Statistically non-significant results were labeled as ns.