TABLE 1.
DNMTs and their expression in various cancers.
| DNMT | Cancer types | Cell/tissue | Expression in cancers | Ref.(PMID) |
|---|---|---|---|---|
| DNMT1 | Lung cancer | HCC827 | + a | 32211850 |
| Gastric cancer | SGC7901, BGC-823, MGC-803, NCI-N87 | + | 33962804 | |
| Breast cancer | MCF-7, T47D, MDA-MB-231, BT549, BT474, SKBR3, Hs578T | + | 31296961 | |
| Pancreatic cancer | PL45, PSN1, Panc1, BxPC3, AxPC1, SW1990, Capan1 | + | 35182659 | |
| 32504382 | ||||
| Prostate cancer | PC3, DU145 | + | 27659015 | |
| Colorectal cancer | HT-29, HCT116, SW620, LoVo | + | 31154022 | |
| DNMT3A | Acute myeloid leukemia | Serum | + c (87.5%) | 34100902 |
| Vulvar squamous cell carcinoma | Epithelium of vulva | +(44%) | 27623253 | |
| Gastric cancer | BGC-823, AGS | + | 33931579 | |
| Lung cancer | A549, NCI-H1395, NCI-H226, NCI-H460, NCI-H520 | + | 27237029 | |
| Colorectal cancer | HCT116, RKO, SW480, SW620 | + | 35414793 | |
| DNMT3B | Endometrial cancer | ISK, KLE | + | 34175897 |
| Colon cancer | HT29, HCT116 | + | 30540937 | |
| Lymphoma | RAJI, Daudi, Akata, JeKo-1, JVM-2, JURKAT, REH, JY | - b | 22133874 | |
| Breast cancer | MDA-MB-231, MCF-7 | + | 30851420 |
a
“+” indicates an increase in expression
b
“-” indicates a decrease in expression
c
The proportion of cases in which the reference mentions up- or downregulation of DNMT