TABLE 2.
Downstream genes or proteins of DNMTs in cancers.
| DNMT | Cancer types | Downstream genes or proteins | Ref.(PMID) |
|---|---|---|---|
| DNMT1 | Lung cancer | Human mutL homolog 1(hMLH1), Human mutS homolog 2 (hMSH2) | 32211850 |
| Gastric cancer | p53 | 33962804 | |
| Breast cancer | Forkhead box O3A (FOXO3a) | 31296961 | |
| Pancreatic cancer | Homeobox B9 (HOXB9) | 35182659 | |
| Prostate cancer | Zinc finger E-box-binding homeobox2 (ZEB2), Kruppel like factor 4 (KLF4) | 27659015 | |
| Colorectal cancer | CDKN1A(p21) | 31154022 | |
| DNMT3A | Acute myeloid leukemia | Cyclin-dependent kinase 1 (CDK1) | 34067359 |
| Vulvar squamous cell carcinoma | Cyclin-dependent kinase inhibitor 2A (CDKN2A) | 27623253 | |
| Gastric cancer | ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9) | 33931579 | |
| Lung cancer | CD147 | 35132181 | |
| Colorectal cancer | TIMP metallopeptidase inhibitor 2 (TIMP2) | 35414793 | |
| DNMT3B | Endometrial cancer | Transcription factor 3 (TCF3) | 34175897 |
| Colon cancer | Interferon regulatory factor 8 (IRF8) | 30540937 | |
| Lymphoma | Met proto-oncogene (MET) | 33418509 | |
| Breast cancer | C-X-C motif chemokine ligand 11 (CXCL11) | 35390315 |