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. Author manuscript; available in PMC: 2022 Sep 8.
Published in final edited form as: Acta Biomater. 2022 Jun 6;148:323–335. doi: 10.1016/j.actbio.2022.05.051

Figure 4: Profound morphological changes correspond to areas of mesh deformation.

Figure 4:

Images of the vaginal epithelium and adventitia of the same mesh-vagina complex from the Predeformed group 12 weeks after surgery. An area where the mesh remained flat after loading is adjacent to an area of pore collapse and wrinkling. In the area where the mesh is flat, the vaginal rugae are normal but are noticeably absent in the areas where the mesh is deformed (right image). Dense fibrotic encapsulation (within the adventitia) is observed in the area of deformed mesh.