Figure 4.

Summary of known factors regulating IGFBP5 expression. Besides proteins that regulate IGFBP5 transcription, namely transcription factors (TFs) (see also Figure 5 ) and chromatin modifiers (CM), other factors have been identified that interfere with IGFBP5 expression. These include other proteins (Wnt, DOG1, Gankyrin), steroids and non-coding RNAs (ncRNAs), namely microRNAs (miRs) and long noncoding RNAs (lncRNAs). Factors that stimulate IGFBP5 expression are denoted in green, those which have a negative effect are shown in red. Factors, which can have either effect dependent on the cellular context, are bicolored.