TABLE 4.

Top 20 genes with highest degree and betweenness in the full retene network. Functional roles were identified using AmiGO 2 (Ashburner et al., 2000; Carbon et al., 2009; Gene Ontology, 2021).

Gene	Functional role	Degree	Gene	Functional role	Betweenness
ahrra	Transcription regulation	40	GeneID.110440109	Uncharacterized	0.10
cyp1c1	Monooxygenase; biotransformation	35	trpc2a	Ion channel activity	0.09
fgf7	Cell proliferation	35	spdya	Protein kinase binding	0.08
cyp1c2	Monooxygenase; biotransformation	35	ppig	Isomerase activity	0.08
cyp1a	Monooxygenase; biotransformation	33	sbno2a	Chromatin DNA binding	0.08
sult6b1	Sulfotransferase; biotransformation	32	phf20b	Metal ion binding; histone acetylation	0.07
tiparp	Metal ion binding	30	celf5b	RNA binding	0.07
GeneID.110366352	Uncharacterized	30	GeneID.100535592	Uncharacterized	0.07
wfikkn1	Peptidase inhibition	30	tmem54a	Integral component of membrane	0.07
GeneID.108182865	Uncharacterized	29	sik2a	ATP binding	0.06
nfe2l2b	Transcription regulation	29	cdc37	Protein stabilization	0.06
ccn2b	Cell adhesion, heparin binding	29	gsr	Cell redox homeostasis	0.06
lonrf1l	Metal ion binding	27	gap43	Regulation of growth	0.06
foxf2a	Transcription regulation	27	si.ch211.173n18.3	Uncharacterized	0.06
cdkn1ba	Kinase inhibitor activity	26	cers3a	Sphingolipid metabolic process	0.06
GeneID.103909114	Uncharacterized	25	josd1	Protein deubiquitinase	0.06
nfe2l2a	Transcription regulation	23	GeneID.103910736	Uncharacterized	0.06
cyb5a	Heme binding	23	gnai3	GTP binding	0.06
gstp1	Glutathione transferase; biotransformation	22	itpr1b	Calcium channel activity	0.06
per2	Circadian clock regulation	21	zgc.100868	Endopeptidase activity	0.06