Table 2.

Top 10 GO and KEGG enrichment of DEGs.

Category	ID	Description	p-value
BP	GO:0031424	Keratinization	1.04E-08
BP	GO:0030216	Keratinocyte differentiation	3.07E-07
BP	GO:0043588	Skin development	1.26E-06
BP	GO:0009913	Epidermal cell differentiation	1.43E-06
BP	GO:0007218	Neuropeptide signaling pathway	5.07E-06
BP	GO:0008544	Epidermis development	2.49E-05
BP	GO:0014821	Phasic smooth muscle contraction	4.64E-05
BP	GO:0038003	Opioid receptor signaling pathway	5.42E-05
BP	GO:0007188	Adenylate cyclase-modulating G protein-coupled receptor signaling pathway	0.000123
BP	GO:0007204	Positive regulation of cytosolic calcium ion concentration	0.00027
BP	GO:0031424	Keratinization	1.04E-08
BP	GO:0030216	Keratinocyte differentiation	3.07E-07
BP	GO:0043588	Skin development	1.26E-06
CC	GO:0045095	Keratin filament	8.18E-05
CC	GO:0005882	Intermediate filament	0.000227
CC	GO:0045111	Intermediate filament cytoskeleton	0.000370
CC	GO:0031225	Anchored component of membrane	0.001451
CC	GO:0005791	Rough endoplasmic reticulum	0.002869
CC	GO:0001533	Cornified envelope	0.009983
CC	GO:0097060	Synaptic membrane	0.010234
CC	GO:0005667	Transcription regulator complex	0.010977
CC	GO:0017146	NMDA selective glutamate receptor complex	0.014357
CC	GO:0062023	Collagen-containing extracellular matrix	0.014529
MF	GO:0008528	G protein-coupled peptide receptor activity	3.09E-05
MF	GO:0001653	Peptide receptor activity	4.02E-05
MF	GO:0008188	Neuropeptide receptor activity	0.000214
MF	GO:0005436	Sodium:phosphate symporter activity	0.001049
MF	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	0.001051
MF	GO:0001216	DNA-binding transcription activator activity	0.001167
MF	GO:0005244	Voltage-gated ion channel activity	0.001600
MF	GO:0022832	Voltage-gated channel activity	0.001600
MF	GO:0036041	Long-chain fatty acid binding	0.001766
MF	GO:0015370	Solute: sodium symporter activity	0.002657