TABLE 1.
Variable | Total cohort (n = 58) | AIH (n = 33) | ASC/PSC (n = 25) |
---|---|---|---|
Sex, n (%) female | 25 (43%) | 15 (46%) | 10 (40%) |
| |||
Race, n (%) White | 55 (95%) | 33 (100%) | 22 (88%) |
| |||
Age at MRI, years | 16 (13, 18) | 16 (13, 18) | 16 (14, 17) |
| |||
Duration of disease from diagnosis to MRI, months | 15 (2, 39) | 14 (2, 39) | 16 (2, 39) |
| |||
IBD diagnosis, n (%) | 19 (33%) | 1 (3%)* | 18 (72%)* |
| |||
Corticosteroid exposure, n (%) | |||
Use at time of MRI | 28 (48%) | 18 (55%) | 10 (40%) |
| |||
Total corticosteroid exposure since diagnosis, n (%) | |||
≥3 months | 35 (60%) | 19 (58%) | 16 (64%) |
<3 months | 10 (17%) | 8 (24%) | 2 (8%) |
None | 13 (22%) | 6 (18%) | 7 (28%) |
Weight, kg at MRI | 65 (51, 75) | 67 (51, 75) | 63 (58, 71) |
Height, cm at MRI | 168 (154, 176) | 165 (149, 171)* | 172 (162, 180)* |
BMI, kg/m2 at MRI | 22 (20, 25) | 23 (20, 25) | 21 (19, 24) |
BMI z score at MRI | 0.61 (−1, 1.4) | 0.7 (0.5, 1.4)* | 0.3 (−0.6, 1.0)* |
BUN (mg/dL) | 11 (9, 12) | 11 (9, 12) | 10 (8, 12) |
Creatinine (mg/dL) | 0.6 (0.5, 0.8) | 0.6 (0.5, 0.7) | 0.7 (0.6, 0.8) |
AST (U/L) | 41 (27, 81) | 47 (34, 83) | 32 (24, 55) |
ALT (U/L) | 65 (31, 91) | 68 (31, 94) | 56 (34, 86) |
Direct bilirubin (mg/dL) | 0.2 (0.1, 0.3) | 0.2 (0.1, 0.3) | 0.1 (0.1, 0.3) |
GGT (U/L) | 55 (17, 172) | 44 (15, 134) | 56 (27, 202) |
Albumin (g/dL) | 3.8 (3.5, 4.1) | 3.9 (3.6, 4.2) | 3.7 (3.5, 4.1) |
INR (s) | 1.1 (1.1, 1.2) | 1.2 (1.1, 1.2) | 1.1 (1.1, 1.1) |
Note: Continuous variables are expressed as median (IQR).
Abbreviations: AIH, autoimmune hepatitis; ALT, alanine aminotransferase; ASC, autoimmune sclerosing cholangitis; AST, aspartate aminotransferase; BMI, body mass index; BUN, blood urea nitrogen; GGT, gamma glutamyl transferase; IBD, inflammatory bowel disease; INR, international normalized ratio; IQR, interquartile range; MRI, magnetic resonance imaging; PSC, primary sclerosing cholangitis.
P value < .05 between the groups.