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. 2022 Sep 8;8:88. doi: 10.1038/s41421-022-00455-6

Fig. 1. Screening for SARS-CoV-2 fusion and entry inhibitors from a cyclic γ-AApeptide library.

Fig. 1

Inhibition of cell–cell fusion mediated by the S protein of SARS-CoV-2 by putative hits at 50 μM (a) and 5 μM (b). The dot line in figures means the inhibition rate of 50% (a) and 80% (b). c Chemical structures of seven hits with inhibitory effect against SARS-CoV-2 S-mediated cell–cell fusion. d Inhibitory activity of hits (S-13, S-20, S-23, S-24, S-25, S-30, and S-32) from SARS-CoV-2 pseudovirus infection assay. e Cytotoxicity of hits (S-13, S-20, S-23, S-24, S-25, S-30, and S-32) on Huh-7 cells.