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. 2022 Sep 8;8:88. doi: 10.1038/s41421-022-00455-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Chemical structures of four modified hits. b HeLa cells incubated with FITC labeled S-20 (i–iii) and FITC labeled S-20-1 (iv–vi) at 1 μM for 2 h, respectively, and then stained with DAPI. (i, iv) DAPI channel; (ii, v) FITC channel; (iii, vi) merged. c Inhibitory activity of 4 modified cyclic γ-AApeptides in PsV infection assays against SARS-CoV-2. d Cytotoxicity of 4 modified cyclic γ-AApeptides on Huh-7 cell line. e Inhibitory activity of S-20-1 on authentic SARS-CoV-2 replication on Caco-2 cell line.