Fig. 9. In vivo safety evaluation of S-20-1.

a Flow diagram of in vivo safety experiments. b Body weight changes of mice administered with S-20-1 or PBS intranasally. c Histological changes of mouse lung, liver, brain, and kidney after administration with S-20-1 or PBS intranasally. Tissues were stained with H&E. The scale bar shown in slides were 1000 µm and 100 µm, respectively.