Table 1. List of Resources and Accompanying Website for Each of the Approaches Presented.

Data resource	Website
Approach 1: Dereplication at the genomic level
NCBI	https://www.ncbi.nlm.nih.gov/
BLAST	https://blast.ncbi.nlm.nih.gov
AntiSMASH	https://antismash.secondarymetabolites.org
AntiSMASH-DB	https://antismashdb.secondarymetabolites.org
IMG/ABC	https://img.jgi.doe.gov/cgi-bin/abc/main.cgi
MIBiG	https://mibig.secondarymetabolites.org
Approach 2: Prioritization based on microbial taxonomy
BiG-SCAPE	https://bigscape-corason.secondarymetabolites.org
CORASON	https://github.com/nselem/corason/wiki
NaPDoS	https://npdomainseeker.sdsc.edu
AutoMLST	https://automlst.ziemertlab.com
Approach 3: Coevolutionary principles to guide discovery
ARTS	https://arts.ziemertlab.com
EvoMining	https://github.com/nselem/EvoMining/wiki
CO-ED	http://enzyme-analysis.org
Approach 4: Retrobiosynthesis to target biosynthetic gene clusters
Approach 5: Molecular networking to identify analogues
GNPS	https://gnps.ucsd.edu
Approach 6: Pairing enzymatic domains with key structural features
IsoAnalyst	https://github.com/liningtonlab/isoanalyst
Approach 7: Paired genome-metabolite databases for discovery
NRPminer	https://github.com/mohimanilab/NRPminer
PoDP	https://pairedomicsdata.bioinformatics.nl
MetaMiner	https://github.com/mohimanilab/MetaMiner