Table 3:
Fold change and p-values of significantly differential miRNAs in IA vs. CONTROL. Most of the miRNAs below are also significantly differential in IACLAD vs CONTROL but are not in IA vs. IACLAD. While miRNAs highlighted in yellow are specific to IA and resistant to the effect of CLAD, those highlighted in blue are also significantly differential in IA vs. IACLAD suggesting that they are CLAD specific miRNAs and are included for illustration purposes only. Bolded and yellow miRNAs are candidates for IA signature.
| IA vs Controls | IACLAD vs Controls | IA vs IACLAD | ||||
|---|---|---|---|---|---|---|
|
| ||||||
| miRNA | Fold Change | pValue | Fold Change | pValue | Fold Change | pValue |
|
| ||||||
| hsa-miR-145-5p | 6.0533 | 1.0870E-05 | 6.3739 | 4.1667E-05 | 0.3206 | 0.5232 |
| hsa-miR-199a-3p+hsa-miR-199b-3p | 4.6122 | 0.0001 | 6.2736 | 0.0001 | 1.6614 | 0.1334 |
| hsa-miR-99b-5p | 4.2809 | 0.0019 | 4.4817 | 0.0086 | 0.2008 | 0.8651 |
| hsa-miR-424-5p | 3.7435 | 0.0005 | 4.0088 | 4.1667E-05 | 0.2653 | 0.7022 |
| hsa-miR-450a-5p | 3.6766 | 0.0050 | 4.4318 | 0.0028 | 0.7552 | 0.5656 |
| hsa-miR-132-3p | 3.5454 | 0.0020 | 3.3363 | 0.0271 | −0.2090 | 0.8583 |
| hsa-miR-195-5p | 3.5252 | 0.0075 | 5.4320 | 0.0002 | 1.9068 | 0.1882 |
| hsa-miR-4284 | 3.4999 | 0.0243 | 4.5749 | 0.0160 | 1.0750 | 0.5678 |
| hsa-miR-199b-5p | 3.4256 | 0.0030 | 6.2736 | 0.0001 | 1.8162 | 0.1891 |
| hsa-miR-2116-5p | 3.0650 | 0.0177 | 5.3854 | 0.0014 | 2.3204 | 0.0635 |
| hsa-miR-503-5p | 3.0500 | 0.0155 | 2.3849 | 0.0464 | −0.6651 | 0.6037 |
| hsa-miR-1290 | 2.9679 | 0.0149 | 5.5064 | 0.0012 | 2.5385 | 0.0595 |
| hsa-miR-548d-3p | 2.9633 | 0.0267 | 5.8144 | 0.0012 | 2.8512 | 0.0460 |
| hsa-miR-542-5p | 2.8258 | 0.0096 | 2.9901 | 0.0123 | 0.1643 | 0.8929 |
| hsa-miR-7-5p | 2.7860 | 0.0052 | 3.8222 | 0.0045 | 1.0363 | 0.4043 |
| hsa-miR-548d-5p | 2.7477 | 0.0294 | 5.8144 | 0.0012 | 2.8512 | 0.0460 |
| hsa-miR-548n | 2.7428 | 0.0437 | 5.8587 | 0.0006 | 3.1159 | 0.0400 |
| hsa-miR-1285-5p | 2.6835 | 0.0255 | 4.8189 | 0.0012 | 2.1354 | 0.1251 |
| hsa-miR-101-3p | 2.6689 | 0.0395 | 1.7690 | 0.1995 | −0.8999 | 0.3981 |
| hsa-miR-2117 | 2.5884 | 0.0183 | 6.1587 | 0.0001 | 3.5703 | 0.0359 |
| hsa-miR-378f | 2.5205 | 0.0194 | 3.4736 | 0.0256 | 3.0899 | 0.0704 |
| hsa-miR-514b-5p | 2.4222 | 0.0210 | 4.3024 | 0.0031 | 1.8802 | 0.0868 |
| hsa-miR-532-3p | 2.4045 | 0.0423 | 1.9728 | 0.1305 | −0.4318 | 0.7189 |
| hsa-miR-217 | 2.4041 | 0.0030 | 1.9702 | 0.0287 | −0.4339 | 0.6403 |
| hsa-miR-125a-3p | 2.3875 | 0.0317 | 3.6409 | 0.0022 | 1.2534 | 0.2945 |
| hsa-miR-4488 | 2.2880 | 0.0351 | 2.9029 | 0.0446 | 0.6149 | 0.5554 |
| hsa-miR-196a-5p | 2.2388 | 0.0045 | 4.9516 | 0.0004 | 2.7127 | 0.0197 |
| hsa-miR-1257 | 2.2140 | 0.0437 | 4.0344 | 0.0060 | 1.8205 | 0.1468 |
| hsa-miR-210-3p | 2.2116 | 0.0224 | 3.3812 | 0.0279 | 1.1696 | 0.4099 |
| hsa-miR-4532 | 2.0959 | 0.0317 | 4.8586 | 0.0025 | 2.7627 | 0.0764 |
| hsa-miR-1249-3p | 2.0465 | 0.0294 | 1.1148 | 0.1875 | −0.9317 | 0.3680 |
| hsa-miR-1305 | 1.9852 | 0.0352 | 4.9723 | 0.0161 | 2.9871 | 0.1099 |
| hsa-miR-574-5p | 1.9384 | 0.0418 | 4.1222 | 0.0032 | 2.1838 | 0.1398 |
| hsa-miR-4516 | 1.9208 | 0.0153 | 3.6549 | 0.0013 | 1.7341 | 0.1798 |
| hsa-miR-877-5p | 1.8178 | 0.0358 | 2.9057 | 0.0086 | 1.0879 | 0.3154 |
| hsa-miR-152-3p | 1.7710 | 0.0384 | 2.4456 | 0.0222 | 0.6746 | 0.5214 |
| hsa-miR-1915-3p | 1.7187 | 0.0358 | 2.5902 | 0.0132 | 0.8715 | 0.2630 |
| hsa-miR-187-3p | −1.3462 | 0.0441 | −2.8924 | 0.0297 | −1.5462 | 0.2263 |
| hsa-miR-4454+hsa-miR-7975 | −1.7458 | 0.0284 | −1.9256 | 0.0219 | −0.1798 | 0.7878 |
| hsa-miR-218-5p | −2.3920 | 0.0083 | −1.1567 | 0.2284 | 1.2354 | 0.2981 |
| hsa-miR-708-5p | −2.8788 | 0.0281 | −1.5909 | 0.1892 | 1.2879 | 0.2931 |