Table 1. Differential Metabolites Characterized in the Serum Profile and Their Change Trend after SA Treatment.

no.	RT	metabolite identification	HMDB	formula	m/z	ion from	P (SAb/Mc)	SA/M	P (M/Bd)	M/B
1	11.060	11,12-epoxyeicosatrienoic acid	HMDB0004673	C20H32O3	319.2279	[M – H]−	1.40 × 10–1		2.04 × 10–2	↓
2	0.849	l-histidine	HMDB0000177	C6H9N3O2	154.2000	[M – H]−	1.84 × 10–10	↓	3.25 × 10–12	↑
3	10.299	palmitic acid	HMDB0000220	C16H32O2	256.2350	[M – H]−	3.61 × 10–2	↑a	4.88 × 10–2	↓
4	12.430	stearic acid	HMDB0000827	C18H36O2	283.2647	[M – H]−	3.98 × 10–2	↑	3.60 × 10–2	↓
5	17.930	linoleic acid	HMDB0000673	C18H32O2	279.4000	[M – H]−	4.39 × 10–2	↑	4.66 × 10–2	↓
6	8.660	tetradecanedioic acid	HMDB0000872	C14H26O4	257.1758	[M – H]−	5.90 × 10–3	↑	3.26 × 10–2	↓
7	1.110	d-leucine	HMDB0013773	C6H13NO2	130.0874	[M – H]−	3.22 × 10–2	↓	1.59 × 10–2	↑
8	1.110	l-leucine	HMDB0000687	C6H13NO2	130.0874	[M – H]−	3.22 × 10–2	↓	1.59 × 10–2	↑
9	10.780	oleic acid	HMDB0000207	C18H34O2	282.2509	[M – H]−	8.24 × 10–4	↑	2.70 × 10–3
10	1.040	l-phenylalanine	HMDB0000159	C9H11NO2	163.9000	[M – H]−	1.43 × 10–2	↓	1.28 × 10–3	↑
11	0.890	l-isoleucine	HMDB0000172	C6H13NO2	131.9010	[M + H]+	2.99 × 10–2	↓	1.24 × 10–2	↑
12	0.903	l-ornithine	HMDB0003374	C5H12N2O2	132.9620	[M + H]+	1.06 × 10–4	↓	6.79 × 10–4	↑
13	1.000	d-proline	HMDB0003411	C5H9NO2	114.0560	[M + H]+	1.41 × 10–5	↓	5.87 × 10–4	↑
14	0.910	proline betaine	HMDB0004827	C7H13NO2	144.1019	[M + H]+	2.60 × 10–5	↓	9.47 × 10–3	↑
15	9.770	eicosapentaenoic acid	HMDB0001999	C20H30O2	303.2319	[M + H]+	1.96 × 10–2	↑	8.57 × 10–3	↓
16	7.770	cytidine	HMDB0000089	C9H13N3O5	243.9400	[M + H]+	1.23 × 10–2	↓	2.32 × 10–5	↑
17	9.110	choline	HMDB0000097	C5H13NO	105.5000	[M + H]+	2.81 × 10–2	↑	6.68 × 10–2	↓
18	7.780	17-HDoHE	HMDB0010213	C23H32O3	357.2424	[M + H]+	1.13 × 10–1		2.43 × 10–2	↓

^aArrow ↑ means a relative increase in signal; arrow ↓ means a relative decrease in signal.

^bSA means sodium artesunate.

^cM means the model group.

^dB means the blank group.