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. 2022 Aug 24;7(35):31482–31494. doi: 10.1021/acsomega.2c04157

Table 2. Main KEGG Pathways Significantly Relating to Major Hubs.

term pathway count pop hits P-value term pathway count pop hits P-value
hsa05417 lipid and atherosclerosis 24 215 4.88 × 10–15 hsa04020 calcium signaling pathway 12 240 3.49 × 10–4
hsa05200 pathways in cancer 31 531 5.72 × 10–12 hsa04520 adherens junction 7 71 3.54 × 10–4
hsa05215 prostate cancer 15 97 2.82 × 10–11 hsa05169 Epstein–Barr virus infection 11 202 3.56 × 10–4
hsa05205 proteoglycans in cancer 18 205 1.44 × 10–9 hsa05218 melanoma 7 72 3.82 × 10–4
hsa04151 PI3K-Akt signaling pathway 22 354 6.42 × 10–9 hsa04115 p53 signaling pathway 7 73 4.12 × 10–4
hsa04210 apoptosis 14 136 2.64 × 10–8 hsa05165 human papillomavirus infection 14 331 4.50 × 10–4
hsa05161 hepatitis B 15 162 2.71 × 10–8 hsa04660 T-cell receptor signaling pathway 8 104 4.64 × 10–4
hsa04657 IL-17 signaling pathway 12 94 4.06 × 10–8 hsa04910 insulin signaling pathway 9 137 4.77 × 10–4
hsa04933 AGE-RAGE signaling pathway in diabetic complications 12 100 7.78 × 10–8 hsa04659 Th17 cell differentiation 8 108 5.83 × 10–4
hsa01521 EGFR tyrosine kinase inhibitor resistance 11 79 8.12 × 10–8 hsa05152 tuberculosis 10 180 6.59 × 10–4
hsa04926 relaxin signaling pathway 13 129 1.27 × 10–7 hsa04621 NOD-like receptor signaling pathway 10 184 7.72 × 10–4
hsa05010 Alzheimer disease 21 384 1.36 × 10–7 hsa04670 leukocyte transendothelial migration 8 114 8.06 × 10–4
hsa05163 human cytomegalovirus infection 16 225 2.66 × 10–7 hsa04215 apoptosis—multiple species 5 32 8.19 × 10–4
hsa05418 fluid shear stress and atherosclerosis 13 139 2.90 × 10–7 hsa05134 legionellosis 6 57 9.44 × 10–4
hsa05223 non-small cell lung cancer 10 72 4.17 × 10–7 hsa05213 endometrial cancer 6 58 1.02 × 10–3
hsa01522 endocrine resistance 11 98 6.39 × 10–7 hsa04071 sphingolipid signaling pathway 8 119 1.04 × 10–3
hsa04914 progesterone-mediated oocyte maturation 11 102 9.29 × 10–7 hsa04935 growth hormone synthesis, secretion, and action 8 119 1.04 × 10–3
hsa04625 C-type lectin receptor signaling pathway 11 104 1.11 × 10–6 hsa04722 neurotrophin signaling pathway 8 119 1.04 × 10–3
hsa04931 insulin resistance 11 108 1.58 × 10–6 hsa04014 Ras signaling pathway 11 232 1.05 × 10–3
hsa04066 HIF-1 signaling pathway 11 109 1.72 × 10–6 hsa04932 non-alcoholic fatty liver disease 9 155 1.08 × 10–3
hsa04915 estrogen signaling pathway 12 138 2.07 × 10–6 hsa04217 necroptosis 9 159 1.27 × 10–3
hsa04668 TNF signaling pathway 11 112 2.21 × 10–6 hsa04611 platelet activation 8 124 1.32 × 10–3
hsa05145 toxoplasmosis 11 112 2.21 × 10–6 hsa05203 viral carcinogenesis 10 204 1.60 × 10–3
hsa05162 measles 12 139 2.22 × 10–6 hsa05132 Salmonella infection 11 249 1.79 × 10–3
hsa05235 PD-L1 expression and PD-1 checkpoint pathway in cancer 10 89 2.58 × 10–6 hsa05164 Influenza A 9 171 2.02 × 10–3
hsa05415 diabetic cardiomyopathy 14 203 2.79 × 10–6 hsa04664 Fc epsilon RI signaling pathway 6 68 2.09 × 10–3
hsa05120 epithelial cell signaling in Helicobacter pylori infection 9 70 3.78 × 10–6 hsa04920 adipocytokine signaling pathway 6 69 2.23 × 10–3
hsa05022 pathways of neurodegeneration—multiple diseases 21 476 4.04 × 10–6 hsa05230 central carbon metabolism in cancer 6 70 2.38 × 10–3
hsa05207 chemical carcinogenesis—receptor activation 14 212 4.52 × 10–6 hsa05206 MicroRNAs in cancer 12 310 2.81 × 10–3
hsa05133 pertussis 9 76 7.06 × 10–6 hsa05140 leishmaniasis 6 77 3.61 × 10–3
hsa05167 Kaposi sarcoma-associated herpesvirus infection 13 194 9.89 × 10–6 hsa04072 phospholipase D signaling pathway 8 148 3.62 × 10–3
hsa04370 VEGF signaling pathway 8 59 1.22 × 10–5 hsa05226 gastric cancer 8 149 3.75 × 10–3
hsa04510 focal adhesion 13 201 1.42 × 10–5 hsa04726 serotonergic synapse 7 115 4.33 × 10–3
hsa05219 bladder cancer 7 41 1.54 × 10–5 hsa04150 mTOR signaling pathway 8 156 4.83 × 10–3
hsa04936 alcoholic liver disease 11 142 1.86 × 10–5 hsa04010 MAPK signaling pathway 11 294 5.87 × 10–3
hsa05222 small cell lung cancer 9 92 2.92 × 10–5 hsa04540 gap junction 6 88 6.37 × 10–3
hsa04152 AMPK signaling pathway 10 120 3.01 × 10–5 hsa00591 linoleic acid metabolism 4 29 6.62 × 10–3
hsa04912 GnRH signaling pathway 9 93 3.16 × 10–5 hsa04650 natural killer cell-mediated cytotoxicity 7 126 6.74 × 10–3
hsa04919 thyroid hormone signaling pathway 10 121 3.21 × 10–5 hsa00590 arachidonic acid metabolism 5 61 8.83 × 10–3
hsa05208 chemical carcinogenesis—reactive oxygen species 13 223 3.99 × 10–5 hsa04024 cAMP signaling pathway 9 221 9.42 × 10–3
hsa04613 neutrophil extracellular trap formation 12 190 4.38 × 10–5 hsa04750 inflammatory mediator regulation of TRP channels 6 98 9.95 × 10–3
hsa05160 hepatitis C 11 157 4.42 × 10–5 hsa04371 apelin signaling pathway 7 139 1.07 × 10–2
hsa01524 platinum drug resistance 8 73 5.00 × 10–5 hsa05146 amebiasis 6 102 1.17 × 10–2
hsa05171 coronavirus disease—COVID-19 13 232 5.87 × 10–5 hsa05017 spinocerebellar ataxia 7 143 1.22 × 10–2
hsa05214 glioma 8 75 5.96 × 10–5 hsa05221 acute myeloid leukemia 5 67 1.22 × 10–2
hsa04068 FoxO signaling pathway 10 131 6.02 × 10–5 hsa04064 NF-kappa B signaling pathway 6 104 1.26 × 10–2
hsa05130 pathogenic Escherichia coli infection 12 197 6.10 × 10–5 hsa04620 toll-like receptor signaling pathway 6 104 1.26 × 10–2
hsa05142 chagas disease 9 102 6.16 × 10–5 hsa04960 aldosterone-regulated sodium reabsorption 4 37 1.30 × 10–2
hsa05212 pancreatic cancer 8 76 6.49 × 10–5 hsa05204 chemical carcinogenesis—DNA adducts 5 69 1.35 × 10–2
hsa05020 prion disease 14 273 6.68 × 10–5 hsa05224 breast cancer 7 147 1.38 × 10–2
hsa05225 hepatocellular carcinoma 11 168 7.85 × 10–5 hsa05202 transcriptional misregulation in cancer 8 193 1.47 × 10–2
hsa05135 Yersinia infection 10 137 8.53 × 10–5 hsa04921 oxytocin signaling pathway 7 154 1.71 × 10–2
hsa04140 autophagy—animal 10 141 1.07 × 10–4 hsa04630 JAK-STAT signaling pathway 7 162 2.13 × 10–2
hsa05131 Shigellosis 13 247 1.07 × 10–4 hsa04810 regulation of actin cytoskeleton 8 218 2.67 × 10–2
hsa04015 Rap1 signaling pathway 12 210 1.08 × 10–4 hsa04380 osteoclast differentiation 6 128 2.83 × 10–2
hsa05170 human immunodeficiency virus 1 infection 12 212 1.18 × 10–4 hsa05032 morphine addiction 5 91 3.34 × 10–2
hsa04012 ErbB signaling pathway 8 85 1.33 × 10–4 hsa04614 renin–angiotensin system 3 23 3.74 × 10–2
hsa05210 colorectal cancer 8 86 1.43 × 10–4 hsa04923 regulation of lipolysis in adipocytes 4 56 3.88 × 10–2
hsa04360 axon guidance 11 182 1.53 × 10–4 hsa04550 signaling pathways regulating pluripotency of stem cells 6 143 4.26 × 10–2
hsa04218 cellular senescence 10 156 2.30 × 10–4 hsa04062 chemokine signaling pathway 7 192 4.37 × 10–2
hsa05231 choline metabolism in cancer 8 98 3.23 × 10–4 hsa04723 retrograde endocannabinoid signaling 6 148 4.82 × 10–2
hsa04917 prolactin signaling pathway 7 70 3.28 × 10–4 hsa04213 longevity regulating pathway—multiple species 4 62 5.00 × 10–2
hsa04930 type II diabetes mellitus 6 46 3.47 × 10–4