Table 1. Conditions affecting IGF-1 and GH levels.

GH: growth hormone; IGF-1: insulin-like growth factor 1

Condition	IGF-1	Basal GH	Nadir GH
Puberty	High	High	High
Pregnancy	High	High	High
Diabetes mellitus	Low/Normal	High	High
Renal failure	Low/Normal	High	High
Liver disease	Low/Normal	High	High
Malnutrition/Anorexia	Low/Normal	High	High
Oral estrogen	Low/Normal	High	High
Critical illness	Low/Normal	High	High