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. 2022 Aug 25;13:968124. doi: 10.3389/fphar.2022.968124

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Copyright © 2022 Fan, Sun, Li, Tang, Li, Yu, Wang, Fan, Xu and Chang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of honokiol on PI3K/AKT/mTOR signaling pathway in the hippocampus. (A) PI3K mRNA expression. (B) AKT mRNA expression. (C) mTOR mRNA expression. Data are expressed as mean ± SEM (n = 6/group). (D) p-PI3K protein expression. (E) p-AKT protein expression. (F) p-mTOR protein expression. (G)The Western blot bands. Data are expressed as mean ± SEM (n = 3/group). ^* p < 0.05 vs. Con group. ^** p < 0.01 vs. Con group. ^*** p < 0.001 vs. Con group. ^# p < 0.05 vs. CUMS group. ^## p < 0.01 vs. CUMS group. ^### p < 0.001 vs. CUMS group.