Table 1.
Top 10 unanswered research priority questions* for hyperemesis gravidarum, in ranked order of importance from one as the most important19
| Ranking | Question* |
| 1 | Can we find a cure? What novel or new treatments are being developed/tested/used elsewhere which could have a curative effect and to address all the symptoms of HG rather than just the vomiting? |
| 2 | How can we most effectively manage HG? What clinical support measure is most important to people who have had hyperemesis and what did they find most beneficial? For example, medical management, pharmaceutical review, nutrition support, rehydration, psychological support |
| 3 | What causes HG? |
| 4 | Is HG preventable? What is the effect of preventative treatment or early intervention on the severity and duration of HG in a subsequent pregnancy? |
| 5 | What are the immediate† and long-term effects‡ of HG (including malnutrition§ and dehydration¶, stress**) on the developing fetus (offspring)? |
| 6 | What are the immediate† and long-term effects‡ of the various medications/treatments on the developing fetus (offspring) throughout the various stages of pregnancy and in varying doses or combinations of treatments? |
| 7 | What are relative†† efficacies of the current medications and treatment options available? What is the optimal dose, route, timing and combination of the medications and what are the related side effects? |
| 8 | What are the immediate† and long term‡, physical, mental and social consequences and complications of HG (including malnutrition and dehydration) on the pregnant person’s body? (ie, metabolic impact, DVT, depression, effects of dehydration) |
| 9 | What clinical measurements and markers are most useful in assessing, diagnosing, managing and monitoring HG? |
| 10 | What are the nutritional requirements of the 1st, 2nd and 3rd trimesters and how can people with HG achieve these goals? That is, oral supplements, fortifying food, dietary measures |
*The phrasing of the questions was established using the James Lind Alliance consensus method therefore we were not able to alter the phrasing in the writing of this manuscript.
†Immediate effects relates to those during the perinatal period.
‡Long-term effects relates to any time after the perinatal period.
§Example indicators of malnutrition include weight loss or nutritional intake.
¶Example indicators of dehydration include need for intravenous rehydration or urine output.
**Stress could be measured with questionnaires.
††Relative to each other.
‡‡
DVT, Deep Vein Thrombosis; HG, hyperemesis gravidarum.