Table 4.

Parameters assessed in the modified Total Neuropathy Score

Parameters	Score
	0	1	2	3	4
Sensory symptoms	None	Symptoms limited to fingers or toes	Symptoms extend to the ankle or wrist	Symptoms extend to the knee or elbow	Symptoms above the knee or elbow or functionally disabling
Motor symptoms	None	Slightly difficult	Moderately difficult	Require help/assistance	Paralysis
Superficial sensitivity	Normal	Reduced in fingers or toes	Reduced up to the wrist or ankle	Reduced up to the elbow or knee	Reduced to above the elbow or knee
Vibratory sensitivity	Normal	Reduced in fingers or toes	Reduced up to the wrist or ankle	Reduced up to the elbow or knee	Reduced to above the elbow or knee
Strength	Normal	Mild weakness (MRC 4)	Moderate weakness (MRC 3)	Severe weakness (MRC 2)	Paralysis (MRC 0–1)
Reflexes	Normal	Ankle reflex reduced	Ankle reflex absent	Ankle reflex absent, others reduced	All reflexes absent

Adapted from Cavaletti et al.⁴²

MRC, Medical Research Council.