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. 2022 Aug 17;9(9):ofac416. doi: 10.1093/ofid/ofac416

Table 2.

Overall Hazard Ratio by Baseline Cerebrospinal Fluid Opening Pressure

Model and Baseline OP HR (95% CI) P Value
14-day mortality (n = 533): unadjusted model
 Baseline OP
  <200 mm H2O 1.31 (.87–1.98) .20
  200–350 mm H2O REF
  >350 mm H2O 1.73 (1.18–2.55) <.01
14-day mortality (n = 470): adjusted modela
 Baseline OP
  <200 mm H2O 1.34 (.83–2.14) .23
  200–350 mm H2O REF
  >350 mm H2O 1.53 (.98–2.38) .06
30-day mortality (n = 533): unadjusted model
 Baseline OP
  <200 mm H2O 1.48 (1.05–2.10) .03
  200–350 mm H2O REF
  >350 mm H2O 1.55 (1.10–2.19) .01
30-day mortality (n = 470): adjusted modela
 Baseline OP
  <200 mm H2O 1.50 (1.01–2.23) .04
  200–350 mm H2O REF
  >350 mm H2O 1.44 (.97–2.13) .07

Abbreviations: CI, confidence interval; H2O, water; HR, hazard ratio; OP, opening pressure.

a

Model adjusted for baseline Glasgow Coma Scale (GCS) score, seizures, focal neurologic deficits, cerebrospinal fluid (CSF) white blood cell count <5 cells/mL, CSF quantitative culture (log10 CFU/mL), hemoglobin. GCS score, seizures, and focal neurologic deficits are likely all on the causal pathway of the effects of elevated intracranial pressure.