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. 2022 Aug 25;9:913046. doi: 10.3389/fvets.2022.913046

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Copyright © 2022 Belij-Rammerstorfer, Limon, Maze, Hannant, Hughes, Tchakarova, Alexandrov, Mmbaga, Willett, Booth, Lyons, Baker, Thomas, Wright, Saunders, Browning, Wilsden, Carroll, Hewson, Charleston, Lambe and Ludi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation and receiver operating characteristic (ROC) analysis of anti-CCHFV Gc-specific and anti-CCHFV NP-specific IgG in-house ELISAs vs. VectoCrimean-CCHF IgG and ID Screen^® CCHF Double Antigen Multi-species commercial kits. A subset of sheep sera collected as part of a cross-sectional study in an endemic CCHFV area (n =8 0) was tested for anti-CCHFV Gc-specific IgG and anti-CCHFV NP-specific IgG by in-house ELISAs and with VectoCrimean-CHF IgG and ID Screen^® CCHF Double Antigen Multi-species commercial kits. Left panel shows spearman correlations between responses evaluated by: (A) anti-CCHFV Gc-specific IgG in-house ELISA and VectoCrimean-CHF IgG, (B) anti-CCHFV NP-specific IgG in-house ELISA and VectoCrimean-CHF IgG, or (C) ID Screen^® CCHF Double Antigen Multi-species. Right panel shows ROC curves generated using: (A) anti-CCHFV Gc-specific in-house ELISA OD measured at 450 nm and positive (n = 41) and negative (n = 39) sera results obtained with VectoCrimean-CHF IgG; (B) anti-CCHFV NP-specific in-house ELISA OD measured at 450 nm and positive (n = 41) and negative (n = 39) sera results obtained with VectoCrimean-CHF IgG, or (C) positive (n = 35) and negative (n = 45) sera results obtained with ID Screen^® CCHF Double Antigen Multi-species.