Figure 6.

N-terminal acetylation of α-synuclein increases the oligomer populations generated during aggregation. (A, B) Relative flux toward oligomeric species formation (Phi) of non-acetylated (A) and acetylated α-synuclein (B) generated from surface-catalyzed fibril amplification data in Figure 5; error bars represent the SEM with n = 3. (C) Area under the curve (Phi AUC) for non-acetylated (blue) and acetylated α-synuclein (red) as a function of monomer concentration; error bars represent the SEM with n = 3. (D) Half time of the surface-catalyzed fibril amplification reactions for non-acetylated (blue) and acetylated α-synuclein (red) as a function of monomer concentration; error bars represent the SEM with n = 3.