Table 3.
H-group | Pat. No | Week 0* | Week 2 | Week 4 | Week 6 | Week 12 | Week 16 | Levela |
1 | 187 | 80 | 54 | 70 | 246 | Discontinuous | ||
2 | 280 | 323 | 137 | 80 | 74 | 154 | Discontinuous | |
3 | 445 | 136 | 299 | 376 | 29 | Continuous | ||
4 | 179 | 172 | 201 | 70 | 43 | Continuous | ||
5 | 230 | 19 | 76 | 48 | 66 | 169 | Discontinuous | |
6 | 1068 | 815 | 856 | 513 | 1060 | 468 | Continuous | |
7 | 678 | 662 | 515 | 624 | 309 | Continuous | ||
8 | 399 | 165 | 362 | 258 | 434 | 381 | Continuous | |
L-group | Pat. No | Week 0* | Week 2 | Week 4 | Week 6 | Week 12 | Week 16 | Level |
9 | 66 | 132 | 145 | 145 | 54 | 47 | Discontinuous | |
10 | 52 | 223 | 209 | 181 | 94 | 35 | Discontinuous | |
11 | 154 | 302 | 155 | 368 | 218 | Continuous | ||
12 | 58 | 140 | 160 | 193 | 170 | 214 | Continuous | |
13 | 137 | 326 | 193 | 215 | 286 | Continuous | ||
14 | 96 | 142 | 200 | 205 | 128 | Continuous | ||
15 | 164 | 111 | 355 | 61 | 81 | 117 | Discontinuous | |
16 | 162 | 132 | 67 | 89 | 151 | Discontinuous |
CICs = BoDV-1-specific circulating immune complexes in blood plasma, specific for BoDV-1 antigens p40/p24. The values of CICs are given as extinction at 405 nm × 1000, measured by enzyme immune assays (EIAs) at the starting dilution of 1:20 for each sample (see Methods). *The initial sampling was at week 0 and represented the basic virological results for H- and L-group patients in this study (see Table 2)
The cut off value of each test is ≥ 100. Results < 100 are regarded negative. H-group = patients with high CICs; L-group = patients with low CICs. aLevel: “Discontinuous” means changing activity levels of infection within 16 weeks (last sampling). “Continuous” means stable activity levels of infection at least for 4 weeks, up to 16 weeks (last sampling)