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. 2022 Sep 8;20:138. doi: 10.1186/s12964-022-00928-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Combination treatment with THZ1 and imatinib for GIST. A CCK-8 viability assay following treatment for 72 h with escalating concentrations of THZ1 and imatinib in GIST-T1 and GIST-882 cells. B GIST-T1 cells received single 20 nmol/L imatinib, THZ1 and a combination treatment for 72 h. GIST-882 cells received single 50 nmol/L imatinib, THZ1 and a combination treatment for 72 h. The cell viability of combination treatment group was significantly suppressed than monotherapy. C Synergy was calculated using CompuSyn, and a combination index value under 1.0 was considered to indicate synergy. D Immunoblotting analysis of cleaved caspase 3 and cleaved PARP protein expression after combination treatment with THZ1 and imatinib in GIST-T1 and GIST-882 cells for 24 h