Scheme 3. Synthesis of Diazepan-5-one Skeleton 11.
Reagents and conditions: (i) Fmoc-β-Ala-OH, HATU, DIPEA, dry DMF, r.t., 16 h; (ii) TFA, TIPS, 1,2-DCE, r.t.; 16 h; (iii) 5 M HCl solution in dioxane, reflux, 16 h, 28 h.
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