Table 17.13.1.
Distinguishing Features of Some Arf GAPs
| Arf GAP | Substrate (Arf1 vs.Arf5 vs. Arf6) | Phosphoinositidea dependence | Other distinguishing features |
|---|---|---|---|
| ArfGAP1 | Arf1 ≥ Arf5 ≥ Arf6 | None | Not determined |
| ASAP1/2/3 | Arf5 ≥ Arf1≫Arf6 | PI(4,5)P2 ≥ PI(3,4,5)P3 | Not determined |
| ACAP1/2 | Arf6>Arf1 = Arf5 | PI(3,5)P2 = PI(4,5)P2 = PIP3 | Not determined |
| ARAP1 | Arf5>Arf1>Arf6 | PI(3,4,5)P3>PIP2 | Not determined |
| ARAP2 | Arf6>Arf5 = Arf1 | PI(3,4,5)P3>PIP2 | Not determined |
| AGAP1/2 | Arf1>Arf5>Arf6 | PIP3=PIP2 | Activation by C-terminal peptide of RhoA |
a
PI (4,5) P2 and PIP2, phosphatidylinositol 4,5-biphosphate; PI (3,5) P2, phosphatidylinositol 3,5-bisphosphate; PI (3,4,5) P3 and PIP3, phosphatidylinositol 3,4,5-triphosphate.