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Mechanism of action for proprotein convertase subtilisin/kexin type 9 (PCSK9) monoclonal antibodies. Monoclonal antibodies against PCSK9 (red) block binding of PCSK9 (brown) to the low-density lipoprotein receptor (LDL-R) (green) and prevent LDL-R degradation, which results in a higher LDL receptor recycling and reduced serum LDL level
