Table 1.

CTCAE^$ 3.0/4.0 grading system for pneumonitis and pulmonary fibrosis

Adverse Event	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
Pneumonitis	Asymptomatic; clinical or diagnostic observations only; intervention not indicated	Symptomatic; medical intervention indicated; limiting instrumental ADL*	Severe symptoms; limiting self care ADL*; oxygen indicated	Life-threatening respiratory compromise; urgent intervention indicated (e.g.,tracheotomy or intubation)	Death
Pulmonary Fibrosis	Mild hypoxemia; radiologic pulmonary fibrosis <25% of lung volume	Moderate hypoxemia; evidence of pulmonary hypertension; radiographic pulmonary fibrosis 25 – 50%	Severe hypoxemia; evidence of rightsided heart failure; radiographic pulmonary fibrosis >50 – 75%	Life-threatening consequences (e.g., hemodynamic/pulmonary complications); intubation with ventilatory support indicated; radiographic pulmonary fibrosis >75% with severe honeycombing	Death

^$CTCAE=Common Terminology Criteria for Adverse Events

^*ADL= Activities of Daily Living.