Table 4.
Examples of dose response modeling: dose-volume metric and probit model parameters recomputed
| Source | Diagnosis; #patients/#lesions | Prescription Dose | OAR definition | Toxicity scheme, grade | Vdose | MLD/MLD2 | Probit model parameters (95% CI) | |
|---|---|---|---|---|---|---|---|---|
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| Ipsilateral lung | ||||||||
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| Ricardi 2009 (48) | NSCLC+lung metastases; 60/63 | 3×15Gy; 1×26Gy | Ipsilateral lung minus CTV | RTOG, grade 2+ | MLD2 | D50=19.7 Gy (17.5, 24.0); | γ50=1.90 (1.13, 3.07) | |
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| Guckenberger 2010 (44) | NSCLC+lung metastases; 59/68 | 3×12.5Gy at 65%; 1×26Gy at 80%; 8×6Gy at 65%; 5×6Gy at 65%; 3×10Gy at 65% | Ipsilateral lung minus CTV | SWOG, grade 2+ | MLD2 | D50=32.2 Gy (18.7, ∞) | γ50=0.59 (0.30, 0.92) | |
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| Ong 2010 (18) | All NSCLC 18/18 | 5×11Gy; 8×7.5Gy | Ipsilateral lung minus PTV | CTCAE v4.0, grade 2+ | V5 | V5,50=54.2 (47.0, 68.3) | γ50=2.46 (0.87, 5.11) | |
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| Combined lung | ||||||||
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| MLD | D50=7.9 (6.7, 9.2) | γ50=4.85 (1.21, m) | ||||||
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| V10 | V10,50=25.8 (19.9, 46.3) | γ50=1.25 (0.41, 2.51) | ||||||
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| V15 | V15,50=19.6 (at limit) | γ50=0.87 (0.00, 1.93) | ||||||
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| Ong 2010 (18) | All NSCLC 18/18 | 5×11Gy; 8×7.5Gy | Combined lung minus PTV | CTCAE v4.0, grade 2+ | V20 | V20,50=16.6 (at limit) | γ50=0.74 (−0.03, 1.71) | |
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| V5 | Threshold behavior, 0% toxicity for V5<36.3%; 100% toxicity for V20>42.8% | Threshold behavior, 0% toxicity for V5<36.3%; 100% toxicity for V20>42.8% | ||||||
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| Borst 2010 (39) | NSCLC/lung metastases; 128/161+ | 4×8.75Gy; 4×10Gy; 8×6Gy; 8×7.5Gy; 4×12Gy | Combined lung minus GTV | CTC v2.0, grade 2+ | MLD2 | D50=23.1 (17.4, 46.7) | γ50=0.82 (0.58 1.08) | |
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| MLD | D50=14.9 (11.2, 29.0) | γ50=0.82 (0.58, 1.08) | ||||||
OAR=organ at risk, CI=confidence interval, NSCLC=Non-small cell lung cancer, GTV=gross tumor volume, CTV=clinical target volume, PTV=planning target volume, RTOG=radiation therapy oncology group, SWOG=southwest oncology group, CTCAE=common terminology criteria for adverse events, MLD=mean lung dose, MLD2=fraction-number-corrected MLD, D50=dose to cause 50% toxicity, Vdose,50=Volume to cause 50% toxicity at dose, γ50=slope parameter, i.e. the percentage point change in response probability per 1% change in dose at the 50% response level.