Table 1.

Confirmed roles of the selected tumor suppressor and oncogene miRNAs in breast cancer. BC = breast cancer, Ref = Reference.

Potential Biomarker Candidates in Breast Cancer Management
Tumor Suppressor miRNAs			OncomiRs
miRNAs	Particular Role(s) in BC	Ref(s)	miRNAs	Particular Role(s) in BC	Ref(s)
miR-7	Suppression of mobility and invasiveness. Regulation of DNA repair.	[22,23]	miR-21	Promoting cell invasion.	[24]
miR-15a	P53-mediated expression. Involved in DNA repair.	[21,25]	miR-135b	Cell growth stimulation and cell cycle disruption.	[26]
miR-16	Cell cycle arrest and regulation of DNA repair.	[21,27]	miR-155	Promoting cell migration and invasiveness. Regulation of DNA repair.	[18]
miR-125b	Prevention of HER-2 overexpression. Suppression of cell proliferation.	[28,29]	miR-181a	Suppression of DNA damage response.	[19]
miR-136	Suppression of cell migration and invasion.	[30]	miR-210	Increasing cell invasiveness and DNA repair regulation.	[31]
miR-181a	Prevention of cancer metastasis.	[32]	miR-221	Promoting cell migration and invasion.	[33]
miR-200a	EMT inhibition.	[34]
miR-200c	EMT inhibition.	[34]
miR-519d	Suppression of cancer metastasis by targeting MMP-3.	[35]
miR-613	Suppression of cell migration and invasion by targeting Daam1.	[36]