Table 3.
List of new FLT3i identified in preclinical studies with sensitivities and resistance repertoire.
| Target | Sensible Mutations | Resistant Mutations | |
|---|---|---|---|
| Pexidartinib (PLX3397) [62] | FLT3ITD, CKIT, CSFR | FLT3ITD, FLT3 F691L | FLT3 D835Y |
| Lu50 [63] | FLT3 | FLT3ITD, FLT3 F691L, FLT3 D835V | - |
| NCGC1481 [64,65] | FLT3, IRAK1/4 | FLT3D835-V,H,Y, FLT3 K663Q, N841I, R834Q, K429A | - |
| FF10101 [66] | FLT3 | FLT3ITD, FLT3 D835, F691, Y842 | - |
| Compound 67 [67] | FLT3ITD | FLT3ITD, FLT3 D835, F691 | - |
| LAM-003 [68] | HSP 90, KDM6A | FLT3ITD, FLT3 D835, F691 | - |
| LT-171-861 [69] | FLT3 | FLT3ITD, FLT3 D854, D835Y, F691L, Y842C | - |
| Compound 17 [70] | FLT3ITD | FLT3ITD, FLT3 F691L, D835-Y,V FLT3 D835-V,H,Y, |
- |
| Compound 8r [71] | FLT3, CAMKK1, TRKC | FLT3ITD NPOS, W51, FLT3 D835Y, FLT3 F594_R595, FLT3R595_E596, FLT3 Y591_V592 | - |
| Compound 5o [72] | FLT3ITD | FLT3 ITD, D835-V,Y, F691L | - |