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. 2022 Aug 28;11(17):2673. doi: 10.3390/cells11172673

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RNA-sequencing data of miR-512-3p overexpression in the HepG2 cells showed reduced oxidative metabolism. (A) Venn diagrams showing mRNAs regulated upon miR-512-3p mimics (M-miR-512-3p) compared to the transfection control (TC). (B) Heatmap of genes regulated by miR-512-3p. (C) Fold-enrichment values of the top five most significantly enriched GO BP, MF, CC, and KEGG pathways. (D) Top 10 significant hallmarks of GSEA downregulated after M-miR-222-5p. Plots were provided for the three most enriched terms. (E) Diagram showing the clustering of STRING analysis. (F) Fold-enrichment values of the top two most significantly enriched terms either in the GO BP, MF, CC, or KEGG pathways in each STRING cluster. Experiments were carried out as three independent replicates.