Figure 5.

Clinical Significance. Classification of somatic variants found in ctDNA of (A) plasma and (B) matching urine samples according to their clinical significance. Using QCI Interpret Translational (QIAGEN), variants were classified into four tiers: Variants in tier I are of strong clinical significance (level A and B evidence), variants in tier II are of potential clinical significance (level C and D evidence), variants in tier III are of unknown clinical significance and variants in tier IV are characterized to be benign or likely benign.