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Schematic representation of differences in the cHL TME in different age groups. EBV-positive paediatric cHL has a more cytotoxic TME with predominant Th1 polarisation, overexpression of CD8, TIA1, TBET, and granzyme B, and fewer FoxP3+ regulatory T cells (Tregs) compared with EBV-negative disease. Fewer granzyme B-positive T cells, increased Tregs, and limited interferon beta production in older adult/elderly EBV-positive cHL indicate a more immunosuppressive TME.
