Figure A2.

Trend-wise and compartmental dissection of expression trends highlight molecular dynamics within the axon through the injury-induced degeneration process. Top upstream regulators, (A) peroxisome proliferator-activated receptor alpha (PPARA) (B) tumour necrosis factor (TNF), and (C) dexamethasone exhibit opposing activation status (as indicated by +/− z-score), mediating opposing directionality of target molecules between 1 dpi and 2 dpi following axotomy. Tables and graphs highlight relative expression of regulatory candidates through 1 dpi and 2dpi compared to 0 dpi as detected by proteomics study published in [124].