Prognostic and predictive performance of DEG and DEmiR. (A) ROC analysis to discriminate patients with recurrence from those with non-recurrence. red indicated higher AUC > 0.75. (B) Univariate Cox regression analysis for disease-free survival. Red indicated higher risk, green indicated lower risk of recurrence, while black indicated no significance. (C) Multivariate Cox regression analysis for disease-free survival adjusted by age, sex, race, and BRAF mutation. Red indicated higher risk, green indicated lower risk of recurrence, while black indicated no significance. Abbreviations: AUC: area under the curve, CI: confidence interval, HR: hazard ratio.