Table 2.
Summary of study characteristics.
| Reference | Study Design | Center | Total No. of Patients | Mean Age | Type of Cancer | Type of Resection | Type of Flap | Mean Duration of Follow-Up (Mo) |
|---|---|---|---|---|---|---|---|---|
| Lefevre 2009 [32] | Observational Prospective |
Monocenter | 43 | 59.5 ± 12.8 | Anal | APR | VRAM | 40.7 (1.5–174.3) |
| Bell 2004 [11] | Observational prospective | Monocenter | 55 | 55 (30–77) | Anal | APR | VRAM | 9 (1–27) |
| Barker 2013 [27] | Observational retrospective | Monocenter | 55 | 65 (38–84) | Anal, rectal | APR | VRAM | NS |
| Combs 2014 [28] | Observational retrospective | Monocenter | 49 | 54.7 ± 11.7 | Anal, rectal | APR | VRAM | 25.6 ± 29.3 |
| Van Ramshorst 2020 [29] | Observational prospective | Monocenter | 87 | 60 (51–66) | Anal, rectal | APR | VRAM | 20 (8–39) |
|
Harries 2021 [30] |
Observational retrospective | Monocenter | 173 | 67 (28–88) | Rectal | APR | VRAM | NS |
| Touny 2014 [31] | Observational prospective | Monocenter | 30 | 53.3 (26–68) | Anal | APR | VRAM | NS |
|
Buchel 2004 [12] |
Observational retrospective | Monocenter | 73 | 56.1 (28–79) | Anal | APR | VRAM | NS |
|
Stein 2018 [26] |
Observational retrospective | Multicenter | 88 | 62.4 (11.6) | Diverse tumors and non-oncologic etiologies | APR | VRAM | NS |
| McMenamin 2011 [33] | Observational retrospective | Monocenter | 16 | 63.6 (29–83) | Diverse tumors and non-oncologic etiologies | APR | VRAM | NS |
| Nelson 2008 [34] | Observational prospective | Monocenter | 114 | 58.0 ± 12.0 | Diverse tumors and non-oncologic etiologies | NS | VRAM | 24.2 20.6 |
| Chong 2005 [35] | Observational retrospective | Monocenter | 16 | 62 ± 8 (53–78) | Diverse tumors | NS | Gracilis | NS |
| Coelho 2019 [36] | Observational retrospective | Monocenter | 25 | 62 (26–80) | Anal, prostate, rectal | NS | Gracilis | 19 (3–102) |
| Sheckter 2016 [37] | Observational retrospective | Monocenter | 16 | 57.94 | Diverse tumors and non-oncologic etiologies | APR | Gracilis | 35 ± 26.8 |
| Stein 2018 [26] | Observational Retrospective |
Multicenter | 27 | 57 (10.7) | Diverse tumors and non-oncologic etiologies | APR | Gracilis | NS |
| Singh 2016 [21] | Observational retrospective | Monocenter | 40 | 56.8 ± 13.9 | Anal | APR | Gracilis | 23.6 |
| Burke 1995 [38] | Observational retrospective | Monocenter | 18 | 55 (33–79) | Vaginal, anal | PE | Gracilis | 25 (2–60) |
Footnote: APR, Abdominoperineal resection; PE, Pelvic exenteration; NS, not specified.