Table 4.

Summary of mRNA fold changes comparison in Urolithin A-treated hAbKI mice and Urolithin A+EGCG treated hAbKI mice.

	Genes	mRNA Fold Change in Urolithin A-Treated hAbKI Mice	mRNA Fold Change in Urolithin A+EGCG-Treated hAbKI Mice
Mitochondrial genes	Drp1	−1.96 *	−2.12 *
	Fis1	−2.32 **	−2.6 **
	Mfn1	2.03 *	8.9 **
	Mfn2	3.4 **	5.23 **
	OPA1	2.91 *	3.76 *
Biogenesis genes	PGC1 alpha	3.03 **	4.1 **
	Nrf1	1.46 *	2.76 ***
	Nrf2	2.39 **	3.25 ***
	TFAM	1.8 *	2.2 **
Synaptic genes	Synaptophysin	3.45 *	3.9 *
	PSD95	2.9 *	3.5 **
	Snap25	3.7 **	6.34 **
	Synapsin 1 Synapsin 2	2.25 10.2 ***	17.03 *** 14.6 ***
	Synaptobrevin 1 Synaptobrevin 2	2.7 * 6.6 **	4.67 ** 7.87 ***
	Neurogranin	3.81 **	8.5 ***
Mitophagy genes	PINK1	2.63 **	3.24 **
	Parkin	2.3 *	2.33 *
Autophagy genes	ATG5	2.07 *	2.23 *
	LC3B	2.08 **	4.34 ***
	BCL2	2.25 *	4.8 **

* = p < 0.05. ** = p < 0.005. *** = p < 0.0005.