Table 4.
Rates of KRAS mutations in lung AC subdivided in different ethnicities.
| KRAS Mutation Rates | ||||
|---|---|---|---|---|
| Caucasians | Asians | Africans | Americans | |
| KRAS exon2 | ||||
| c.34G > T (p.G12C) | 34% | 24.5% | NA | 41.2% |
| c.35G > T (p.G12V) | 21% | 1.5% | NA | 19% |
| c.35G > A (p.G12D) | 14% | 25.5% | 28.5% | 15% |
| c.35G > C (p.G12A) | 9.5% | 1.3% | NA | 7% |
| c.34G > A (p.G12S) | 1% | 0.6% | NA | 1% |
| c.34G > C (p.G12R) | 1% | 0.6% | NA | 1% |
| c.37G > T (p.G13C) | 4% | 0.7% | NA | 7% |
| c.38G > A (p.G13D) | 1–2% | 0.7% | 42.8% | 1% |
| c.37G > C (p.G13R) | 0.5% | 0.5% | NA | 0.5% |
| c.37G > A (p.G13S) | NR | NR | NR | NR |
| KRAS exon3 | ||||
| c.183A > C (p.Q61H) | 1% | 0.8% | NA | 4% |
| c.182A > T (p.Q61L) | 0.5% | 0.4% | NA | 1% |
| c.182A > G (p.Q61R) | 0.06% | 0.05% | NA | 0.05 |
| c.180_181delinsAA (p.Q61K) | 0.02% | NR | NA | 0.02 |
| c.181C > G (p.Q61E) | NR | NR | NA | NR |
| c.176C > A (p.A59E) | NR | NR | NA | NR |
| c.176C > G (p.A59G) | NR | NR | NA | NR |
| c.175G > A (p.A59T) | NR | NR | NA | NR |
| KRAS exon4 | NR | NR | NA | NR |
| c.436G > C (p.A146P) | NR | NR | NA | NR |
| c.436G > A (p.A146T) | NR | NR | NA | NR |
| c.437C > T (p.A146V) | NR | NR | NA | NR |