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. 2022 Aug 26;11(17):2656. doi: 10.3390/cells11172656

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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MLC1 upregulates ICl,_swell currents in U251 astrocytoma cells. (A) Representative I–V relationships recorded from −100 to +100 mV pulses (Delta 20 mV, holding potential −40 mV, duration 1 s) in U251 cells infected with an empty vector (Ø) (top), expressing MLC1-WT (middle) or MLC1-S280L mutant (bottom) in control condition (left), following application of hyposmotic solution (center) and after digital subtraction (Hypo-Iso, right). (B,C) Mean I–V relationships of instantaneous and steady state current obtained in MLC1-Ø (black; n = 6), MLC1-WT (red; n = 9), and MLC1-S280L cells (grey; n = 6) after digital subtraction (Hypo-Iso) (mean ± SEM; * p < 0.05; *** p < 0.001).