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. 2022 Aug 26;14(17):4123. doi: 10.3390/cancers14174123

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Multifunctional magnetic nanoparticles for co-delivery of miRNA-let7a and doxorubicin to improve therapeutic response and overcome drug resistance [77]. Copyright © 2018, American Chemical Society. (a) Design of the MCNP construct for simultaneous delivery of miRNA and anticancer drugs (e.g., DOX).; (b) MCNP construct is decorated with iRGD peptide, enabling the tumor-targeted delivery via α_Vβ₃ integrin-mediated uptake. (c) Co-delivery of miRNA (let-7a) sensitizes cancer cells to DOX therapy via inhibition of multiple chemoresistance-related genes, including those associated in drug efflux and DNA repair mechanisms.