Figure 5.

Diminished complex I respiration in mitochondria as well as increased cardiac and skeletal muscle synthase activity in R6/1 mice treated with rosiglitazone. OCR data from isolated cardiac (A) and soleus muscle (D), complex I respiration in cardiac (B) and soleus muscle (E) mitochondria, and cardiac (C) and skeletal muscle (F) citrate synthase activity in R6/1 (HD) and R6/1 with rosiglitazone treated mice (HD + Rosiglitazone). Data presented as mean ± SEM, n = 4–6, * p < 0.05, ** p < 0.01. The red dotted lines present the mean value of the investigated parameter in control, C57BL/6J mice (adapted from supplementary materials). Due to the methodological inability to compare the obtained values with values from other experiments conducted on Seahorse metabolic analyzer, values from control experiments (wild-type mice) are not shown. Nevertheless, the comparison of the OCR values between control and HD mice models is present in the supplementary materials.