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Genomics and transcriptional landscape of BPDCN. The genomic landscape of BPDCN include a combination of myeloid-like and lymphoid-like mutations and cytogenetic defects within a complex landscape, with frequent complex karyotypes. The transcriptional program of BPDCN is made of a diversity of original factors: RUNX2, MYB, IFN pathway, neural processes, cholesterol metabolism, corticoresistance factor, and original oncogenic factors.
