Table 2.

Multivariable proportional hazard Cox models for overall survival.

Parameter	Value	Univariate p	Multivariable p	Multivariable HR	HR 95% Confidence Limits
Liver curative surgery	No	<0.0001	<0.0001	1.77	1.43; 2.17
Concomitant extrahepatic disease	Yes	0.003	0.0442	1.27	1.01; 1.61
Isolated liver metastasis	No	<0.0001	0.0022	1.44	1.14; 1.82
Nodal involvement of primary	Yes	<0.0001	0.0051	1.28	1.08; 1.53
First-line PO-SACT	No	0.0008	0.0003	1.50	1.21; 1.87
Use of anti-EGFR mAb	No	0.081	0.0491	1.24	1.00; 1.55
PO-SACT duration	Long	0.001	0.0460	1.18	1.00; 1.39

EGFR: epithelial growth factor receptor; HR: hazard ratio; mAb: monoclonal antibody; PO-SACT: pre-operative systemic anticancer therapy.