Table 3.
Adverse Event | Any n (%) | Grade 3 ≥ n (%) |
---|---|---|
Total adverse events | 126 (96.9%) | 47 (36.1%) |
Liver injury | 57 (43.8%) | 8 (6.1%) |
Hypertension | 54 (41.5%) | 9 (6.9%) |
Proteinuria | 37 (28.5%) | 12 (9.2%) |
Fatigue | 36 (27.6%) | 1 (0.7%) |
Skin disorder | 32 (24.6%) | 1 (0.7%) |
Fever | 30 (23.0%) | 2 (1.5%) |
Hoarseness | 21 (16%) | 0 (0.0%) |
Decreased appetite | 20 (15.3%) | 0 (0.0%) |
Hypothyroidism | 18 (13.8%) | 0 (0.0%) |
Diarrhea | 17 (13.0%) | 1 (0.7%) |
Bleeding | 17 (13.0%) | 9 (6.9%) |
Hypopituitarism | 3 (2.3%) | 3 (2.3%) |
Heart failure | 3 (2.3%) | 3 (2.3%) |
Drug-induced pneumonia | 2 (1.5%) | 2 (1.5%) |
Infusion reaction | 5 (3.8%) | 0 (0.0%) |
Abbreviations: Atezo/Beva, atezolizumab plus bevacizumab.