1) Weekly.

2) Routine follow-up per standard of care, usually every 3 months in year 1–2 and every 4–6 months in year 3–5, yearly thereafter.

3) Pelvic exam as performed for response assessment prior to the brachytherapy.

4) As indicated during the brachytherapy procedure.

5) Cone beam CT can be useful for response assessment and is important for adaptive planning.

6) MRI preferred to define the tumor extent in the pelvis, which can also assist in radiation therapy planning pre-treatment and for brachytherapy.

7) MRI 1 month post-therapy for response assessment.

8) Preferred, if available, for assessment of lymph node involvement and distant metastases.

9) PET/CT 3 months post-therapy for response assessment.

10) Feasible weekly during radiation therapy along with standard-of-care blood collections for chemotherapy.

11) Feasible weekly or at prospective time points/dose levels during/after treatment

12) Challenging but potentially feasible.

13) Uniquely feasible in cervical cancer during a brachytherapy procedure.