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. 2022 Aug 24;14(17):4092. doi: 10.3390/cancers14174092

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HLA-DR expression influences the spatial relationship of immune and epithelial cells (ECs). (A) ANOVA analysis of the intercellular distance between ECs and T cells in high and low HLA-DR expressing tumors. (B) Bivariate comparison of HLA-DR-positive surface area and engagement between EC and T cells. ANOVA analysis of (C) intercellular distance and (D) engagement between T helper cells and ECs. ANOVA analysis of (E) intercellular distance and (F) engagement between cytotoxic T cells (CTL) and ECs relative to HLA-DR expression. (G) Bivariate analysis comparing engagement of CTLs and ECs with APCs to T helper cells. ANOVA analysis of engagement between CTLs and (H) PD-L1⁻ and (I) PD-L1⁺ relative to HLA-DR expression.