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. 2022 Aug 24;14(17):4092. doi: 10.3390/cancers14174092

Figure 4.

Figure 4

HLA-DR expression influences the proportion of activated immune cells in the TME. (A) ANOVA analysis of the percent of immune cells (CD3+ T cells and CD163+ APCs) relative to all cells in high and low HLA-DR expressing tumors. (B) ANOVA analysis of the percent of T helper cells relative to all cells in high and low HLA-DR expressing tumors. (C) Percent surface area of HLA-DR staining in patients with high (upper quartile) and low (lowest quartile) T helper cell infiltration. (D) Bivariate analysis of HLA-DR-positive surface area and percentage of T helper cells of all cells. Relative abundance of (E) total T cells and (F) cytotoxic T cells in high and low HLA-DR-expressing tumors.