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. 2022 Aug 24;14(17):4092. doi: 10.3390/cancers14174092

Figure 5.

Figure 5

HLA-DR expression is associated with greater immune and epithelial cell population mixing in the TME. Representative phenotypic maps are shown of (A) high and (B) low T helper cell macrophage mixing (CD3+ T cells (blue), pancytokeratin-positive epithelial cells (pink), CD163+ antigen-presenting cells (orange), and other cells (gray). (C) ANOVA analysis of the area under the curve (AUC) of G-function curves, a mathematical representation of population-level cellular mixing between high and low HLA-DR expressing tumors. Representative phenotypic maps are shown of (D) high and (E) low CTL to epithelial cell mixing. (F) ANOVA analysis comparing G-function AUCs between high and low HLA-DR-expressing tumors.