Figure 3.

Neuronal remodeling is detectable across several fiber classes. (A–H): Quantification of the nerve fiber hypertrophy (A) and nerve fiber density (B) for Calcitonin Gene-Related Peptide (CGRP)-positive fibers (peptidergic nociceptive fibers), Tyrosine hydroxylase (TH)-positive fibers (sympathetic fibers and C-low threshold mechanoreceptors) and Neurofilament Protein 200 (NF200)-positive fibers (A beta fibers). The number of investigated mice is given in brackets. Representative images are shown in (C–H) (scale bar = 100 µm). Data are presented as mean ± S.E.M. * p < 0.05 in comparison between KPPC and control mice, Student’s t-test.